Burdock root attenuates preneoplastic lesion development.

This post was originally published on this sitePMID:  Environ Toxicol. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804025 Abstract Title:  Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis. Abstract:  Nonalcoholic steatohepatitis (NASH) is considered growing risk factor for hepatocellular carcinoma development in high-income countries. […]

Arctium lappa root extract prevents lead-induced liver injury.

This post was originally published on this sitePMID:  Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282 Abstract Title:  Root Extract Prevents Lead-Induced Liver Injury by Attenuating Oxidative Stress and Inflammation, and Activating Akt/GSK-3β Signaling. Abstract:  L () is a popular medicinal plant with promising hepatoprotective activity. This study investigated the protective […]

Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.

This post was originally published on this sitePMID:  Neurotoxicol Teratol. 2019 Oct 20 ;77:106838. Epub 2019 Oct 20. PMID: 31644948 Abstract Title:  Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny. Abstract:  Paracetamol (PAR) is an over-the-counter medicine used as analgesic or antipyretic by 40-50% of the pregnant women in different countries. […]

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.

This post was originally published on this sitePMID:  J Biochem Mol Toxicol. 2019 Nov 27:e22427. Epub 2019 Nov 27. PMID: 31777137 Abstract Title:  Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats. Abstract:  The study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were […]

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.

This post was originally published on this sitePMID:  Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895 Abstract Title:  Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats. Abstract:  Paracetamol (PAR) and diclofenac (DF) are the most popular consumed analgesics and anti-inflammatory medications.This study aimed to explore the protective effect of […]

Tanshinone IIA reduces subsequent apoptosis and remodelling while increasing survival proteins in H9c2 cardiomyoblasts.

This post was originally published on this sitePMID:  Int J Med Sci. 2017 ;14(12):1284-1291. Epub 2017 Sep 30. PMID: 29104486 Abstract Title:  Tanshinone IIA Inhibitsβ-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis. Abstract:  Cardiomyopathy involves changes in the myocardial ultra-structure, hypertrophy, apoptosis, fibrosis and inflammation. Angiotensin […]

Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test.

This post was originally published on this sitePMID:  Pharm Biol. 2017 Dec ;55(1):2264-2269. PMID: 29171356 Abstract Title:  Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test. Abstract:  CONTEXT: Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear.OBJECTIVE: To study the antifatigue […]

Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway.

This post was originally published on this sitePMID:  Mol Med Rep. 2018 Feb ;17(2):2384-2392. Epub 2017 Nov 24. PMID: 29207086 Abstract Title:  Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway. Abstract:  Tanshinone IIA (Tan IIA), as a bioactive compound extracted from the dried roots of Salvia miltiorrhiza (also known as Danshen), is […]

Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver.

This post was originally published on this sitePMID:  Exp Ther Med. 2017 Nov ;14(5):4639-4646. Epub 2017 Sep 21. PMID: 29201162 Abstract Title:  Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver. Abstract:  Oxidative stress is a crucial factor associated with fatty liver disease, which raises the possibility of […]

Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway.

This post was originally published on this sitePMID:  Mol Med Rep. 2018 Aug ;18(2):1899-1908. Epub 2018 Jun 26. PMID: 29956801 Abstract Title:  Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway. Abstract:  Hypoxic ischemic encephalopathy (HIE) is the most common brain injury following hypoxia and/or ischemia caused by various factors during the perinatal […]

Tanshinone IIA attenuates paraquat‑induced acute lung injury.

This post was originally published on this sitePMID:  Mol Med Rep. 2018 Sep ;18(3):2955-2962. Epub 2018 Jul 16. PMID: 30015919 Abstract Title:  Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats. Abstract:  Tanshinone IIA (TIIA) is an active compound that can be isolated from the Chinese herb, Salvia miltiorrhizae Bunge, also […]

Tanshinone IIA pretreatment protects H9c2 cells against anoxia/reoxygenation injury

This post was originally published on this sitePMID:  Oxid Med Cell Longev. 2018 ;2018:3583921. Epub 2018 Jun 28. PMID: 30050654 Abstract Title:  Tanshinone IIA Pretreatment Protects H9c2 Cells against Anoxia/Reoxygenation Injury: Involvement of the Translocation of Bcl-2 to Mitochondria Mediated by 14-3-3. Abstract:  Tanshinone IIA is an important component that is isolated from danshen (), […]

Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1.

This post was originally published on this sitePMID:  Eur J Pharmacol. 2019 Aug 15 ;857:172419. Epub 2019 May 25. PMID: 31136758 Abstract Title:  Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1. Abstract:  Advanced glycation end products (AGEs) play an important role in the onset of diabetic retinopathy. Therefore, […]

Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure.

This post was originally published on this sitePMID:  Acta Cir Bras. 2019 ;34(8):e201900807. Epub 2019 Oct 14. PMID: 31618407 Abstract Title:  Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure. Abstract:  PURPOSE: To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart […]

Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells.

This post was originally published on this sitePMID:  Oncol Lett. 2019 Dec ;18(6):6554-6562. Epub 2019 Nov 1. PMID: 31807174 Abstract Title:  Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathway. Abstract:  Epithelial-to-mesenchymal transition (EMT) is an essential phenotypic conversion involved in cancer progression. Epidermal growth factor (EGF) and […]

Agastache honey has superior antifungal activity in comparison with important commercial honeys.

This post was originally published on this sitePMID:  Sci Rep. 2019 Dec 3 ;9(1):18197. Epub 2019 Dec 3. PMID: 31796803 Abstract Title:  Agastache honey has superior antifungal activity in comparison with important commercial honeys. Abstract:  There is an urgent need for new effective antifungal agents suitable for the treatment of superficial skin infections, since acquired […]

Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition.

This post was originally published on this sitePMID:  Int Immunopharmacol. 2019 Dec ;77:105968. Epub 2019 Nov 6. PMID: 31704290 Abstract Title:  Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis. Abstract:  Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder leading to progressive tissue fibrosis. […]

Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth.

This post was originally published on this sitePMID:  Aging (Albany NY). 2019 Nov 11 ;11(21):9719-9737. Epub 2019 Nov 11. PMID: 31711043 Abstract Title:  Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway. Abstract:  Tanshinone IIA (TanIIA)-an active constituent of, a traditional Chinese medicinal plant-is known […]

Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis.

This post was originally published on this sitePMID:  Neurochem Int. 2019 Nov 25:104610. Epub 2019 Nov 25. PMID: 31778727 Abstract Title:  Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Abstract:  Our previous data indicated that tanshinone IIA (tan IIA) improves learning and memory in a mouse model of […]

Tanshinone IIA reverses gefitinib-resistance in human non-small-cell lung cancer.

This post was originally published on this sitePMID:  Onco Targets Ther. 2019 ;12:9355-9365. Epub 2019 Nov 7. PMID: 31807016 Abstract Title:  Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway. Abstract:  Background: Gefitinib-resistance is a primary obstacle for the treatment of non-small-cell lung cancer (NSCLC). It has been shown that tanshinone […]

Manuka honey microemulsion eye cream could be used as a treatment for blepharitis.

This post was originally published on this sitePMID:  Ocul Surf. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31759183 Abstract Title:  Randomized masked trial of the clinical efficacy of MGO Manuka Honey microemulsion eye cream for the treatment of blepharitis. Abstract:  PURPOSE: To assess the clinical efficacy of a novel MGO Manuka Honey microemulsion (MHME) […]

Manuka honey-based wound dressings are a promising treatment for infected chronic wounds.

This post was originally published on this sitePMID:  Sci Rep. 2019 Dec 3 ;9(1):18160. Epub 2019 Dec 3. PMID: 31796774 Abstract Title:  Honey can inhibit and eliminate biofilms produced by Pseudomonas aeruginosa. Abstract:  Chronic wound treatment is becoming increasingly difficult and costly, further exacerbated when wounds become infected. Bacterial biofilms cause most chronic wound infections […]

Royal jelly reduces depression-like behaviour.

This post was originally published on this sitePMID:  Biosci Biotechnol Biochem. 2019 Nov 20:1-7. Epub 2019 Nov 20. PMID: 31746674 Abstract Title:  Royal jelly reduces depression-like behavior through possible effects on adrenal steroidogenesis in a murine model of unpredictable chronic mild stress. Abstract:  Royal jelly (RJ) is used as a dietary supplement for human health […]

Nigella sativa oil mouth rinse improves chemotherapy-induced oral mucositis in patients with acute myeloid leukemia.

This post was originally published on this sitePMID:  Biomed Res Int. 2019 ;2019:3619357. Epub 2019 Oct 30. PMID: 31781612 Abstract Title:  Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia. Abstract:  Objective: The present study aims at evaluating the beneficial effect of(NS) oil mouth rinse in the management of chemotherapy- (CT-) […]

N. sativa extract significantly decreases the severity of acute radiation dermatitis and delays the onset of moist desquamation in breast cancer patients.

This post was originally published on this sitePMID:  Complement Ther Med. 2019 Dec ;47:102205. Epub 2019 Oct 3. PMID: 31780017 Abstract Title:  Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial. Abstract:  OBJECTIVE: The present study aimed to evaluate the effectiveness of Nigella sativa L. (N. […]

Quercetin alleviated lipopolysaccharide-stimulated injury by up-regulating miR-124.

This post was originally published on this sitePMID:  Biofactors. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804760 Abstract Title:  Quercetin alleviates lipopolysaccharide-induced inflammatory responses by up-regulation miR-124 in human renal tubular epithelial cell line HK-2. Abstract:  Chronic kidney disease (CKD) is a persistent kidney structural and functional disorder. Quercetin is one of active extracted […]

Quercetin could be more effective in inhibiting metastasis compared to resveratrol.

This post was originally published on this sitePMID:  Nutr Cancer. 2019 Oct 9:1-12. Epub 2019 Oct 9. PMID: 31595775 Abstract Title:  The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell. Abstract:  Resveratrol and quercetin are phytochemicals that are found in a variety of plants. The aim of this study was […]

Resveratrol attenuates malathion-induced liver damage by reducing oxidative stress.

This post was originally published on this sitePMID:  J Lab Physicians. 2019 Jul-Sep;11(3):212-219. PMID: 31579256 Abstract Title:  Resveratrol attenuates malathion-induced liver damage by reducing oxidative stress. Abstract:  BACKGROUND: Malathion is an organophosphate insecticide which disrupts the antioxidant system of the body. Resveratrol is a phytoestrogen and antioxidant of the red grape.AIM AND OBJECTIVE: This study […]

Neuroprotective effects of resveratrol in Alzheimer’s disease.

This post was originally published on this sitePMID:  Front Biosci (Elite Ed). 2020 Jan 1 ;12:139-149. Epub 2020 Jan 1. PMID: 31585875 Abstract Title:  Neuroprotective effects of resveratrol in Alzheimer’s disease. Abstract:  Alzheimer’s disease (AD) is a neurodegenerative disorder, which is commonly seen in older individuals. This is characterized by cognitive dysfunction, which leads to […]