Burdock root attenuates preneoplastic lesion development.

This post was originally published on this sitePMID:  Environ Toxicol. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804025 Abstract Title:  Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis. Abstract:  Nonalcoholic steatohepatitis (NASH) is considered growing risk factor for hepatocellular carcinoma development in high-income countries. […]

Arctium lappa root extract prevents lead-induced liver injury.

This post was originally published on this sitePMID:  Antioxidants (Basel). 2019 Nov 24 ;8(12). Epub 2019 Nov 24. PMID: 31771282 Abstract Title:  Root Extract Prevents Lead-Induced Liver Injury by Attenuating Oxidative Stress and Inflammation, and Activating Akt/GSK-3β Signaling. Abstract:  L () is a popular medicinal plant with promising hepatoprotective activity. This study investigated the protective […]

Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.

This post was originally published on this sitePMID:  Neurotoxicol Teratol. 2019 Oct 20 ;77:106838. Epub 2019 Oct 20. PMID: 31644948 Abstract Title:  Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny. Abstract:  Paracetamol (PAR) is an over-the-counter medicine used as analgesic or antipyretic by 40-50% of the pregnant women in different countries. […]

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.

This post was originally published on this sitePMID:  J Biochem Mol Toxicol. 2019 Nov 27:e22427. Epub 2019 Nov 27. PMID: 31777137 Abstract Title:  Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats. Abstract:  The study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were […]

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.

This post was originally published on this sitePMID:  Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895 Abstract Title:  Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats. Abstract:  Paracetamol (PAR) and diclofenac (DF) are the most popular consumed analgesics and anti-inflammatory medications.This study aimed to explore the protective effect of […]

Tanshinone IIA reduces subsequent apoptosis and remodelling while increasing survival proteins in H9c2 cardiomyoblasts.

This post was originally published on this sitePMID:  Int J Med Sci. 2017 ;14(12):1284-1291. Epub 2017 Sep 30. PMID: 29104486 Abstract Title:  Tanshinone IIA Inhibitsβ-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis. Abstract:  Cardiomyopathy involves changes in the myocardial ultra-structure, hypertrophy, apoptosis, fibrosis and inflammation. Angiotensin […]

Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test.

This post was originally published on this sitePMID:  Pharm Biol. 2017 Dec ;55(1):2264-2269. PMID: 29171356 Abstract Title:  Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test. Abstract:  CONTEXT: Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear.OBJECTIVE: To study the antifatigue […]

Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway.

This post was originally published on this sitePMID:  Mol Med Rep. 2018 Feb ;17(2):2384-2392. Epub 2017 Nov 24. PMID: 29207086 Abstract Title:  Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway. Abstract:  Tanshinone IIA (Tan IIA), as a bioactive compound extracted from the dried roots of Salvia miltiorrhiza (also known as Danshen), is […]

Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver.

This post was originally published on this sitePMID:  Exp Ther Med. 2017 Nov ;14(5):4639-4646. Epub 2017 Sep 21. PMID: 29201162 Abstract Title:  Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver. Abstract:  Oxidative stress is a crucial factor associated with fatty liver disease, which raises the possibility of […]

Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway.

This post was originally published on this sitePMID:  Mol Med Rep. 2018 Aug ;18(2):1899-1908. Epub 2018 Jun 26. PMID: 29956801 Abstract Title:  Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway. Abstract:  Hypoxic ischemic encephalopathy (HIE) is the most common brain injury following hypoxia and/or ischemia caused by various factors during the perinatal […]

Tanshinone IIA attenuates paraquat‑induced acute lung injury.

This post was originally published on this sitePMID:  Mol Med Rep. 2018 Sep ;18(3):2955-2962. Epub 2018 Jul 16. PMID: 30015919 Abstract Title:  Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats. Abstract:  Tanshinone IIA (TIIA) is an active compound that can be isolated from the Chinese herb, Salvia miltiorrhizae Bunge, also […]

Tanshinone IIA pretreatment protects H9c2 cells against anoxia/reoxygenation injury

This post was originally published on this sitePMID:  Oxid Med Cell Longev. 2018 ;2018:3583921. Epub 2018 Jun 28. PMID: 30050654 Abstract Title:  Tanshinone IIA Pretreatment Protects H9c2 Cells against Anoxia/Reoxygenation Injury: Involvement of the Translocation of Bcl-2 to Mitochondria Mediated by 14-3-3. Abstract:  Tanshinone IIA is an important component that is isolated from danshen (), […]

Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1.

This post was originally published on this sitePMID:  Eur J Pharmacol. 2019 Aug 15 ;857:172419. Epub 2019 May 25. PMID: 31136758 Abstract Title:  Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1. Abstract:  Advanced glycation end products (AGEs) play an important role in the onset of diabetic retinopathy. Therefore, […]

Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure.

This post was originally published on this sitePMID:  Acta Cir Bras. 2019 ;34(8):e201900807. Epub 2019 Oct 14. PMID: 31618407 Abstract Title:  Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure. Abstract:  PURPOSE: To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart […]

Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells.

This post was originally published on this sitePMID:  Oncol Lett. 2019 Dec ;18(6):6554-6562. Epub 2019 Nov 1. PMID: 31807174 Abstract Title:  Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathway. Abstract:  Epithelial-to-mesenchymal transition (EMT) is an essential phenotypic conversion involved in cancer progression. Epidermal growth factor (EGF) and […]

Agastache honey has superior antifungal activity in comparison with important commercial honeys.

This post was originally published on this sitePMID:  Sci Rep. 2019 Dec 3 ;9(1):18197. Epub 2019 Dec 3. PMID: 31796803 Abstract Title:  Agastache honey has superior antifungal activity in comparison with important commercial honeys. Abstract:  There is an urgent need for new effective antifungal agents suitable for the treatment of superficial skin infections, since acquired […]

Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition.

This post was originally published on this sitePMID:  Int Immunopharmacol. 2019 Dec ;77:105968. Epub 2019 Nov 6. PMID: 31704290 Abstract Title:  Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis. Abstract:  Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder leading to progressive tissue fibrosis. […]

Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth.

This post was originally published on this sitePMID:  Aging (Albany NY). 2019 Nov 11 ;11(21):9719-9737. Epub 2019 Nov 11. PMID: 31711043 Abstract Title:  Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway. Abstract:  Tanshinone IIA (TanIIA)-an active constituent of, a traditional Chinese medicinal plant-is known […]

Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis.

This post was originally published on this sitePMID:  Neurochem Int. 2019 Nov 25:104610. Epub 2019 Nov 25. PMID: 31778727 Abstract Title:  Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Abstract:  Our previous data indicated that tanshinone IIA (tan IIA) improves learning and memory in a mouse model of […]

Tanshinone IIA reverses gefitinib-resistance in human non-small-cell lung cancer.

This post was originally published on this sitePMID:  Onco Targets Ther. 2019 ;12:9355-9365. Epub 2019 Nov 7. PMID: 31807016 Abstract Title:  Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway. Abstract:  Background: Gefitinib-resistance is a primary obstacle for the treatment of non-small-cell lung cancer (NSCLC). It has been shown that tanshinone […]

Manuka honey microemulsion eye cream could be used as a treatment for blepharitis.

This post was originally published on this sitePMID:  Ocul Surf. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31759183 Abstract Title:  Randomized masked trial of the clinical efficacy of MGO Manuka Honey microemulsion eye cream for the treatment of blepharitis. Abstract:  PURPOSE: To assess the clinical efficacy of a novel MGO Manuka Honey microemulsion (MHME) […]

Manuka honey-based wound dressings are a promising treatment for infected chronic wounds.

This post was originally published on this sitePMID:  Sci Rep. 2019 Dec 3 ;9(1):18160. Epub 2019 Dec 3. PMID: 31796774 Abstract Title:  Honey can inhibit and eliminate biofilms produced by Pseudomonas aeruginosa. Abstract:  Chronic wound treatment is becoming increasingly difficult and costly, further exacerbated when wounds become infected. Bacterial biofilms cause most chronic wound infections […]

Royal jelly reduces depression-like behaviour.

This post was originally published on this sitePMID:  Biosci Biotechnol Biochem. 2019 Nov 20:1-7. Epub 2019 Nov 20. PMID: 31746674 Abstract Title:  Royal jelly reduces depression-like behavior through possible effects on adrenal steroidogenesis in a murine model of unpredictable chronic mild stress. Abstract:  Royal jelly (RJ) is used as a dietary supplement for human health […]

Nigella sativa oil mouth rinse improves chemotherapy-induced oral mucositis in patients with acute myeloid leukemia.

This post was originally published on this sitePMID:  Biomed Res Int. 2019 ;2019:3619357. Epub 2019 Oct 30. PMID: 31781612 Abstract Title:  Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia. Abstract:  Objective: The present study aims at evaluating the beneficial effect of(NS) oil mouth rinse in the management of chemotherapy- (CT-) […]

Garlic Effective at Lowering Blood Pressure

This post was originally published on this siteIf you have been diagnosed with high blood pressure and are concerned about the harms associated with blood-pressure drugs — and you should be — you may want to add some garlic to your meal

N. sativa extract significantly decreases the severity of acute radiation dermatitis and delays the onset of moist desquamation in breast cancer patients.

This post was originally published on this sitePMID:  Complement Ther Med. 2019 Dec ;47:102205. Epub 2019 Oct 3. PMID: 31780017 Abstract Title:  Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial. Abstract:  OBJECTIVE: The present study aimed to evaluate the effectiveness of Nigella sativa L. (N. […]

Quercetin alleviated lipopolysaccharide-stimulated injury by up-regulating miR-124.

This post was originally published on this sitePMID:  Biofactors. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804760 Abstract Title:  Quercetin alleviates lipopolysaccharide-induced inflammatory responses by up-regulation miR-124 in human renal tubular epithelial cell line HK-2. Abstract:  Chronic kidney disease (CKD) is a persistent kidney structural and functional disorder. Quercetin is one of active extracted […]